Esketamine / SPRAVATO® NASAL SPRAY

For individuals battling treatment-resistant depression (TRD), esketamine nasal spray offers a promising alternative to traditional therapies that haven't provided relief. With Spravato, you can unlock new hope.

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What is ESKETAMINE?

Esketamine, marketed under the brand name Spravato, is an FDA-approved prescription nasal spray used alongside an oral antidepressant to treat adults with treatment-resistant depression (TRD). This innovative psychiatric treatment is administered under the supervision of a trained professional at Psychiatry Treatment Centers to ensure safety and effectiveness. By targeting the underlying causes of major depressive disorder (MDD), Esketamine treatment provides a fast-acting option for those who have not found relief with traditional medication management alone.

Unlike conventional antidepressants, which primarily target serotonin and other neurotransmitters, esketamine works differently by targeting the brain's glutamate system. By binding to NMDA receptors, esketamine helps increase the production of brain-derived neurotrophic factor, a protein essential for neuron growth and forming new neural connections.

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Benefits Of SPRAVATO®

Spravato's unique mechanism of action targets depressive symptoms and supports brain health in ways that conventional antidepressants do not. Unlike traditional oral medications, Spravato is delivered via a nasal spray, producing fast-acting relief.

If you struggle with treatment-resistant depression, here's how Spravato may benefit you:

  • Experience faster onset of symptom relief
  • Increase brain activity and plasticity
  • Improve mood regulation
  • Decrease suicidal ideation
  • Minimize medication side effects
  • Receive personalized dosing

Discover long-lasting relief with SPRAVATO®

The positive effects of a single Spravato treatment can persist for weeks or even months. Experience the extended relief from depression symptoms you deserve.

At Psychiatry Treatment Centers, we understand the challenges of finding the most suitable mental health treatment for your needs. Our dedicated team of trained professionals, including psychiatric providers, nurses, and support staff, is fully committed to guiding you through the decision-making process. We help determine if Spravato (Esketamine) is the right choice for your treatment-resistant depression (TRD). With a focus on personalized treatment and medication management, we ensure a seamless, well-coordinated treatment experience tailored to your individual mental health goals.


Once you and your doctor have determined that Spravato is the appropriate treatment for you, we can collaborate with you to complete a patient intake form, which will initiate your Spravato treatment. Our expert staff takes a proactive approach in coordinating your care and will maintain open communication with your primary care doctor to monitor your progress.

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If you’ve taken two or more oral antidepressants and still experience symptoms of depression, you might have treatment-resistant depression (TRD).

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Psychiatric & Emotional Support For

  • Depression or MDD
  • Other Mood Disorders
  • Anxiety Disorder
  • OCD
  • ADD & ADHD
  • PTSD
  • Substance Abuse

FEATURED REVIEW

See what one patient had to say about Psychiatry Treatment Centers services! Have a question? We can help.

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"The staff has been courteous and helpful. I have seen Courtney Ta three times and she listens deeply. We are collaborating towards improving my focus and sleep. I’m overly sensitive to medications so we keep revising the protocol and trying new things. I appreciate her expertise and flexibility."

Esketamine Safety and Personalized Care

During each session, patients are monitored by a qualified member of our team to observe any immediate reactions and to manage any side effects that may arise. After we administer the Spravato nasal spray, you’ll remain at the clinic for observation before being cleared to leave.

Our high care standards help you get the most out of treatment.

Spravato safety and monitoring protocols help minimize side effects while maximizing benefits.

  • Continuous Supervision: Each session is closely monitored by a psychiatric provider to manage potential side effects.
  • Tailored Treatment Plans: Dosages and frequency of sessions are customized to meet individual patient needs.
  • Post-Administration Observation: Patients remain under medical supervision after each treatment to ensure safety.
  • Ongoing Evaluation: Progress is regularly assessed to adjust treatment plans as necessary.

If you struggle with depression symptoms, reach out to us about esketamine today. Advocating for your mental health is a courageous, proactive step to finding the relief you deserve. And we’re here to support you every step of the way.

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Find SPRAVATO® in Southern California and SOUTHEAST Georgia

At Psychiatric Treatment Centers, we believe that everyone deserves access to high-quality mental health care. Our approach to esketamine treatment for depression is holistic, addressing both the physical and psychological aspects of this challenging condition. Through the careful administration of esketamine, we help individuals manage their depressive symptoms, foster resilience, and build stronger connections with themselves and others.

We partner with you by creating a supportive and confidential environment and providing the tools and guidance you need to lead a healthier, more fulfilling life. Take the first step toward better mental well-being today.

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OUR ESKETAMINE & SPRAVATO® FAQ

If you have questions about esketamine or Spravato, you're not alone. Check out the frequently asked questions below or call us for more information: (833) 4-PTCMED. We've also included a video below called "Nicole's Story" that provides a real life scenario for Spravato use.

  • What is esketamine or Spravato used for?

    Esketamine is primarily used for the treatment of treatment-resistant depression (TRD) in adults. It is prescribed when other antidepressants have not been effective in alleviating depressive symptoms. Esketamine is also used, in some cases, as part of a treatment plan for major depressive disorder (MDD) with acute suicidal ideation or behavior.


    Esketamine is administered as a nasal spray under the brand name Spravato, and it is used in conjunction with an oral antidepressant. The treatment is typically administered in a healthcare setting due to the need for monitoring after each dose.

  • How does Spravato make you feel?

    SPRAVATO® can cause sleepiness, dizziness, spinning sensations, or the feeling of being disconnected from yourself, your thoughts, space and time (dissociation). Be sure to review our pdf download for more information or contact us.

  • How long does esketamine stay in your system?

    Esketamine has a relatively short half-life, ranging from 7 to 12 hours. Given this half-life, it generally takes about 2 to 3 days for esketamine to be eliminated from the body. However, the exact duration can vary based on several factors, including the individual's metabolism, age, liver function, dosage, and frequency of use.


    Although the drug itself is cleared from the system relatively quickly, its effects on the brain can persist for a longer period. This is one reason why patients are monitored closely after administration. Additionally, because esketamine is typically used in a controlled clinical setting, healthcare providers manage the dosing schedule to minimize potential risks.

  • How often do you take esketamine?

    The frequency of administration can vary depending on the phase of treatment and the patient's response. Here is a general outline:


    Induction Phase (First 4 Weeks): Esketamine is usually administered twice a week.


    Maintenance Phase: After the initial 4 weeks, the frequency is generally reduced to once a week. Depending on the patient's response, it may then be further reduced to once every 2 weeks.


    The exact dosing schedule can vary based on the patient's condition, response to treatment, and the guidance of the healthcare provider. Regular follow-ups are important to adjust the dosing schedule as needed and to monitor for any side effects or adverse reactions.

  • How long do people stay on Spravato?

    Research suggests that the minimum recommended duration for Spravato treatment, in combination with an oral antidepressant, is at least six months for patients with treatment-resistant depression.

  • Does Spravato cause weight gain?

    Spravato itself does not typically cause weight gain. However, the oral antidepressant taken alongside Spravato may contribute to weight changes, depending on the specific medication prescribed. If weight gain is a concern, discuss it with your healthcare provider.

  • What is the difference between ketamine and esketamine?

    Ketamine is a racemic mixture containing both R-ketamine and S-ketamine (esketamine). Esketamine, the active ingredient in Spravato, is a more potent form of ketamine, allowing for lower doses and potentially fewer side effects. Ketamine is often administered intravenously, while esketamine is delivered via a nasal spray. Esketamine is FDA-approved specifically for treatment-resistant depression, while ketamine is used off-label for similar purposes.

PTC Med free mental health quiz

OUR SIMPLE DEPRESSION & ANXIETY QUIZ

Our free online assessments can help you measure the intensity of your depression or anxiety symptoms and monitor any variations over time. Our PHQ-9 and GAD-7 questionnaires do not collect any personal information from you, so your responses will remain completely anonymous. You can bookmark or favorite these quizzes for future reference in order to track your progress over time.

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