Spravato® Cost: 5 Factors That Influence What You Pay

When considering specialized mental health treatments, cost is often an important part of the decision-making process. Esketamine, marketed under the brand name Spravato®, is an FDA-approved treatment for treatment-resistant depression (TRD) and for major depressive disorder with suicidal thoughts or actions. Out-of-pocket costs for Spravato® can vary based on several factors, including medication pricing, insurance coverage, and the structure of care.

At Psychiatry Treatment Centers, we believe that understanding the financial side of treatment can help you feel more prepared and informed. Below are five key factors that commonly influence the cost of Spravato® treatment and what you may pay.

1. The cost of Spravato® medication

One factor that affects overall cost is the price of the medication itself. Like many prescription medications, the cost of Spravato® may change over time and can vary based on manufacturer pricing, location, and other considerations.

Esketamine is currently available only under the brand name Spravato®, and there is no generic version at this time. Because of this, lower-cost generic alternatives are not available, which can influence overall pricing.

2. Insurance coverage for Spravato® nasal spray

Insurance coverage plays a significant role in determining what you pay for Spravato® treatment. Many insurance plans cover a portion of the cost, though coverage details vary depending on your specific plan.

Some insurers require prior authorization before approving Spravato® treatment. In these cases, your provider can work directly with your insurance company to submit the necessary documentation and help guide you through the approval process.

3. Spravato® administration and monitoring costs

Although Spravato® is self-administered as a nasal spray, it must be taken in a certified Spravato® (esketamine) treatment center under clinical supervision. During each visit, your provider guides you through administration and monitors your response.

After dosing, you’ll remain in a private observation space for a required monitoring period, typically about two hours. During this time, clinical staff check vital signs and support comfort and safety. These services are part of the overall cost of care and reflect the clinical expertise and monitoring required for each session.

4. Esketamine treatment duration

Spravato® treatment takes place over multiple sessions, and the total number of visits can affect overall cost. Sessions are usually scheduled weekly or biweekly during the initial phase of treatment, followed by maintenance visits based on individual response and clinical recommendations.

Your treatment schedule is personalized and may change over time depending on your diagnosis, symptom improvement, and provider guidance. The duration of care is one reason total costs can vary from person to person.

5. Financial assistance and support programs

Financial support may be available to help reduce out-of-pocket costs for Spravato®, regardless of whether you have insurance. Some state programs, including Medicaid-based pharmaceutical assistance programs, may offer additional support depending on eligibility.

You may also explore manufacturer-sponsored programs, such as:

Johnson & Johnson assistance program

Spravato® is manufactured by Johnson & Johnson, which offers assistance programs designed to help eligible individuals access prescribed medications. These programs may provide support for those facing affordability challenges. Read about this program.

Spravato® withMe program

Spravato® withMe is a patient support program that offers cost support and rebate options for eligible individuals receiving esketamine treatment. Program availability and benefits vary based on eligibility.Learn more about Spravato® withMe.

Tips for managing Spravato® costs

Planning ahead can make managing treatment costs feel more approachable. Consider the following steps as you prepare:

Review your insurance benefits: Understanding your plan’s coverage can help clarify expected costs.
Ask your clinic for details: Once prior authorization is complete, clinics can often outline estimated costs and payment options.
Use health savings options: Health savings accounts (HSAs) or flexible spending accounts (FSAs) may be used to cover eligible out-of-pocket expenses.
Visit the Spravato® website: The manufacturer’s website provides information about savings programs and financial support resources.

Learn more about Spravato® at Psychiatry Treatment Centers

At Psychiatry Treatment Centers, we aim to support individuals throughout every step of care, including understanding treatment options and navigating insurance and costs. Spravato® treatment is currently available at our Southern California clinics.

In Southeast Georgia, our clinics provide select mental health services via telemedicine, and TMS therapy is available at our Hinesville location. Spravato® treatment is not currently offered in Georgia.

Reach out to our team by phone today for more information or to schedule an initial appointment. You can also book your initial appointment online now.